The most popular invasive skin care treatment methods include:
1. Platelet-rich plasma (PRP) treatment
2. Needle mesotherapy
3. PDO (polydioxanone) lifting threads
4. Botulinum toxin type A injection
5. Carboxytherapy
Qualified individuals perform these treatments. The descriptions of these treatments are for information and based on desk research. I have included a summary of the most cited research on each procedure to help you decide what will work best for you. These descriptions should in no way be construed as recommendations.
Platelet-Rich Plasma (PRP) Treatment
Blood comprises plasma, red blood cells, white blood cells, and blood clotting elements called thrombocytes of blood platelets. PRP treatment entails injecting plasma enriched with platelets into the skin. The procedure triggers tissue reconstruction at the cellular level. The treatment claims to restore skin firmness and elasticity, and it is used to treat acne scars and accelerate hair growth.
Modest improvement in facial skin appearance, texture, and lines was observed. Fine lines and pigmentation below the eyes may also benefit. The injections are regarded to be safe and modestly beneficial for aging skin. However, the persistence of these effects requires further trials (Maisel-Campbell, A.L. et al. 2020; Yuksel, E.P. et al. 2014).
A randomized clinical trial studied the impact of PRP injections on the visual appearance, texture, and color of photodamaged facial skin. The fine and coarse texture of the skin improved significantly with a single treatment of PRP. The improvements observed were nominal. (Alam, M., et al 2018). The treatment was evaluated for efficacy and safety in human facial rejuvenation. Collagen levels increased. PRP application could be considered an effective and safe procedure (Abuaf et al., et al. 2016; Kim, D.H. et al. 2011). A single treatment was well tolerated (Elnehrawy et al., 2017).
Needle Mesotherapy
The therapy is performed with the help of a special device or traditionally with a needle. Various preparations containing hyaluronic acid or combined with vitamins, inorganic salts, glycerin, or trace elements matched to the patient’s need are injected into a previously anesthetized skin. The treatment claims to improve blood circulation and color, nourish and hydrate the skin, level existing wrinkles, prevent skin aging and sagging on the abdomen, thighs, and arms, and help contour the face. Medspas recommend four to six treatments annually to make the skin look brighter and give it a lifting effect.
Mesotherapy, developed in the mid-1950s by Dr. Michel Pistor in France to manage pain and vascular disorders, has gained popularity recently. It uses new substances like platelet-rich plasma, peptides, growth factors, and collagens. The treatment was used to treat localized pain and other clinical conditions. It is also widely used to eliminate disfiguring fat (Sivagnanam, G. 2010).
However, the data to evaluate the technique's safety are lacking, and scientific researchers consider its use debatable (Konda, D et al., 2013). No significant impact on skin rejuvenation has been noted, and multivitamins and hyaluronic acid solution facial mesotherapy do not appear to benefit significantly (Amin S. P. et al. 2006).
Therefore, emphasis is being laid on the usefulness of informed consent until scientific evidence on the mechanism of action and application is arrived at. (Mammucari, M., et al 2020). Additional clinical and experimental studies are necessary to establish the safety and efficacy of this treatment. Vedamurthy, M. (2007), Herreros, F, O.C et al 2011).
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